In general, living tissue needs oxygen and nutrients to thrive, and with wounds, it is needed to regenerate healthy tissue.
In normal wound healing
the wound either requires conditions of
- hypoxia or
- normal levels of oxygen (i.e. normoxia)
These different conditions occur in all phases of wound healing.
A wound is dependent on both the supply of oxygen to the wound tissue, which is determined by the pulmonary gas exchange and the blood haemoglobin level.
The cardiac output of the patient, the perfusion rate, and the number of capillaries around the wound along with the consumption rate of parenchymal and stromal cells determine these levels.
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Throughout all phases of wound healing, oxygen plays a substantial role. Its effects vary depending on whether the wound is in a hypoxic, normoxic, or in a hyperoxic state.
The following are the key points.
- First, during energy metabolism, oxygen is needed for mitochondrial cytochrome oxidase. This, in turn, produces high-energy phosphates which then are needed for many cellular functions.
- Second, in collagen synthesis oxygen is involved in the hydroxylation of proline and lysine into procollagen which leads to collagen maturation.
- Third, in angiogenesis, hypoxia is required to start the process, but it has been shown that if oxygen is administered it can accelerate and sustain vessel growth.
- Finally, the antimicrobial action of oxygen occurs when converted by leukocytic NADPH oxidase to a superoxide ion which kills bacteria.
So, by supplying the oxygen the wound needs, the speed of healing is improved, and is that not what we all want! So please have a look at bound-oxygen.com to see what options are available.